Custom Peptides
Cayman Chemical 6-bromo-MDMAhydrochlorIde 10mg
A PROTAC that drives WDR5 degradation induces degradation of WDR5 in MV4-11 cells (DC50 53 nM) reduces WDR5 protein levels but not levels of mRNA encoding WDR5 in MV4-11 cells at 1 UM
Cayman Chemical 1 3DIdocosnoyl2Oleoyl Gly 10mg
A sterol has been found in dust samples from urban and rural paved and agricultural and public unpaved roads has been used as an internal standard for the quantification of phytosterols by HPLC-MS/MS and fecal sterols by GC-FID and GC-MS
Cayman Chemical 2 1 8NaphthyrIdIn2ylphen 10mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids a potential metabolite of MDMB-4en-PICA based on the published metabolism of MDMB-PICA intended for research and forensic applications
Cayman Chemical 11-hydroxy Testosteron 10mg
A potential impurity in commercial preparations of gabapentin has been used as a precursor in the synthesis of 5-HT2A receptor antagonists
Cayman Chemical Lentztrehalose C 10mg
A Bcl2-BH4 domain antagonist (Ki 3.3 nM) selective for Bcl-2 over Bcl-xL Mcl-1 A1/Bfl-1 and Bcl-2 lacking the BH4 domain (Kis 500 500 500 and 654.8 nM respectively) binds to BH1- BH2- or BH3 domain-deficient Bcl-2 (Kis 12.4 7.6 and 23.4 nM respectively) induces Bax activation in HT cells which lack endogenous Bcl-2 and in HT cells overexpressing Bcl-2 indicating a context-specific Bcl-2-independent mechanism of cell death is cytotoxic against a panel of NSCLC and SCLC cell lines (IC50s 0.2-1.73 UM) reduces tumor growth and induces tumoral caspase-3 activation in an H460 lung cancer mouse xenograft model at 10 20 and 30 mg/kg
Cayman Chemical Fmoc-Glu OtBu-OSu 1g
A small molecule inhibitor of RPA selectively binds to and inhibits DBD-F on RPA70 up to 100 UM inhibits etoposide-induced autophosphorylation of ATR kinase and subsequent phosphorylation of RPA32 in UMSCC38 cells at 10 and 20 UM reduces tumor growth in UMSCC11B and UMSCC38 mouse xenograft models at 1 mg/kg when used in combination with etoposide
Cayman Chemical AurothIoglucosehydrate 10mg
An analytical reference standard that is structurally similar to known phytocannabinoids regulated as a Schedule I compound in the United States intended for research and forensic applications
Cayman Chemical DavuntIdeacetate 10mg
An anti-integrin peptide protects against hydroquinone-induced necrosis and apoptosis as well as inhibits hydroquinone-induced production of ROS in RPE cells at 400 UM decreases expression of BAX VEGFA and ITB1 in human AMD cybrid cell lines at 20 mg/ml arrests aberrant blood vessel growth mediated by aVB3 aVB5 and a5B1 integrins in vivo
Cayman Chemical KN-93phosphate 10mg
A natural antitumor inhibitor of cell adhesion to extracellular matrix that potently and selectively inhibits PP2A (IC50 29 nM against the catalytic subunit) while having no effect against PP1 PP2B or PP5
Cayman Chemical 1 4D-Xylopentaose 10mg
A TRPM8 agonist induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 12 UM) selective for TRPM8 over TRPV1-4 and TRPA2 at 1 mM reduces capsaicin-induced nocifensive behavior in mice at 6 nmol i.c.v. induces analgesia in the hot plate test in mice
Cayman Chemical 3-HydroxygenkwnIn 10mg
A RIPK1 inhibitor (IC50 13 nM) selective for RIPK1 over RIPK3 at 10 UM as well as over a panel of additional kinases at 2 UM inhibits Z-VAD-FMK-induced necrosis in HT-29 cells (EC50 28 nM) reduces TNF-a-induced lethality and protects against TNF-a-induced organ damage in a mouse model of SIRS at 6 mg/kg reduces spinal cord demyelination and BBB breakdown in a mouse model of EAE reduces hepatic inflammatory cell infiltration and fibrosis as well as body weight gain and total fat mass in a mouse model of high-fat diet-induced NASH at 300 mg/kg
Cayman Chemical 2-O-MonsuccInyladenosIn-3 10mg
An inhibitor of the Hec1-Nek2 interaction binds to Hec1 and reduces Nek2 protein levels in HeLa cells at 25 UM inhibits the growth of various breast cancer cells (GI50s 10 5-20 5 UM) inhibits migration of MDA-MB-231 cells in a transwell migration assay (IC50 176 nM) reduces tumor growth in an MDA-MB-468 mouse xenograft model at 50 and 100 mg/kg
Cayman Chemical DImethIndenmaleate 10mg
Source Recombinant human N-terminal His-tagged DPP-10 expressed in HEK293 cells Amino acids 56-796 MW 87.4 kDa
Cayman Chemical HederacosIde C 10mg
A DOPA decarboxylase inhibitor (ED50 21.8 mg/kg) a2-adrenergic receptor agonist metabolized to a-methylnorepinephrine in the CNS has antihypertensive activity in vitro and in vivo improves trophoblast and endothelial cellular interaction in vitro
Cayman Chemical Lusutrombopag 10mg
An active metabolite of clindamycin formed via S-oxidation of clindamycin primarily by CYP3A4 inhibits the growth of P. prevotti B. fragilis and C. sordelli in vitro (MICs 2 2 and 1 mg/L respectively)